Palabras clave
comunicación celular
microambiente tumoral
cáncer
Cómo citar
Resumen
El Factor de Crecimiento Transformante-beta o TGF-β (Transforming Growth factor-β) es el prototipo más estudiado de una familia de proteínas multifuncionales que regulan, a múltiples, procesos celulares, como la proliferación, la diferenciación y la muerte, en el desarrollo embrionario y en organismos adultos. El TGF-β es también uno de los factores supresores de tumores más potentes, ya que en las células de origen epitelial o hematopoyético inhibe la proliferación celular y promueve la muerte, a diferencia de su desregulación que provoca el desarrollo de la fibrosis, el cáncer y las enfermedades autoinmunes. Esta revisión se enfoca en particular, a la descripción y el análisis de los mecanismos moleculares implicados en la síntesis, secreción, activación y acción del TGF-β, con énfasis en el contexto del cáncer.
Citas
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