Resumen
Las estadísticas de La Federación Internacional de Diabetes refieren que, en el año 2019, había un aproximado de 463 millones de adultos con diabetes mellitus (DM), y la probabilidad de aumentar a 853 millones para el año 2050. Entre las consecuencias de padecerla sin atención, son las complicaciones crónicas graves como el daño al sistema nervioso, la ceguera, la insuficiencia cardíaca y renal, problemas dentales, y los accidentes cerebrovasculares, entre otras. En la actualidad, algunos medicamentos antidiabéticos como la Metformina tienen limitaciones y efectos secundarios, por lo que ha crecido el interés en el uso de agentes naturales para su tratamiento. Un ejemplo a notar es el uso de las plantas del género Costus spp. conocida con los nombres comunes de apagafuego, huilamote o caña brava en diferentes estados de México; el género consta de aproximadamente 175 especies. Se ha demostrado que su consumo, tiene efectos favorables en la reducción del colesterol y de la hemoglobina glicosilada, pero también en el aumento del glucógeno hepático; con efectos comparables a los del fármaco Glibenclamida. Por lo expuesto, el objetivo de este trabajo fue realizar una revisión del avance en el uso potencial de las plantas del género Costus como hipoglucemiante en pacientes diabéticos y su relación con el control de la hiperglucemia para evitar daños oculares, renales y nerviosos.
Citas
Abouelwafa, E., Zaki, A., Sabry, O. M., El-Shiekh, R. A., Caprioli, G. & Abdel-Sattar, E. (2024). Unveiling the chemical profiling and remarkable modulation of carbohydrate metabolism by costus root, Dolomiaea costus (Falc.) in streptozotocin (STZ)-induced diabetic rats. Journal of Ethnopharmacology, 326, 117911. https://doi.org/10.1016/j.jep.2024.117911
Akani, N. P., Nwachukwu, C. & Hakam, I. O. (2020). Evaluation of the Antibacterial Activity of Gongronema latifolium and Costus afer Leaf Extracts on E. coli (ATCC 29455) and S. aureus (ATCC 25923). International Journal of Pathogen Research, 5(4), 11-16. DOI: 10.9734/ijpr/2020/v5i430139
Ali, H. A., Almaghrabi, O. A. & Afifi, M. E. (2014). Molecular mechanisms of anti-hyperglycemic effects of Costus speciosus extract in streptozotocin-induced diabetic rats. Saudi Medical Journal, 35(12), 1501-1506. PMID: 25491216; PMCID: PMC4362175
Alzahrani, A. M., Alshareef, R. J., Balubaid, M. M., Alzahrani, M., Alsoubhi, M. & Shaheen, M. (2023). Perception and attitude of type 2 diabetic patients toward insulin therapy in the primary care of National Guard for Health Affairs (NGHA) in Jeddah, Saudi Arabia. Journal of Family Medicine and Primary Care, 12(11), 2768-2773. DOI: 10.4103/jfmpc.jfmpc_2484_22
Amalan, V., Vijayakumar, N., Indumathi, D. & Ramakrishnan, A. (2016). Antidiabetic and antihyperlipidemic activity of p-coumaric acid in diabetic rats, role of pancreatic GLUT 2: In vivo approach. Biomed Pharmacother, 84, 230-236. PMID: 27662473. DOI: 10.1016/j.biopha.2016.09.039
Arivu, I., Muthulingam, M. & Selvakumar, G. (2023). Detailed study on Costus igneus plant for its medicinal importance-A review. International Journal of Zoology and Applied Biosciences, 8(1), 34-39. DOI: org/10.55126/ijzab.2023.v08.i01.005
Awanish, P., Poonam, T., Rishabh, P., Rashmi, S. & Shambaditya, G. (2011). Alternative therapies useful in the management of diabetes: A systematic review. Journal of Pharmacy and Bioallied. Sciences, 3, 504-512. DOI: 10.4103/0975-7406.90103
Bakhshwin, D., Faddladdeen, K. A. J., Ali, S. S., Alsaggaf, S. M. & Ayuob, N. N. (2022). Nanoparticles of Costus speciosus Ameliorate Diabetes-Induced Structural Changes in Rat Prostate through Mediating the Pro-Inflammatory Cytokines IL 6, IL1β and TNF-α. Molecules, 27(3), 1027. DOI: 10.3390/molecules27031027
Basto-Abreu, A., López-Olmedo, N., Rojas-Martínez, R., Aguilar-Salinas, C. A., Moreno-Banda, G. L., Carnalla, M., Rivera, J. A., Romero-Martinez, M., Barquera, S. & Barrientos-Gutiérrez, T. (2023). Prevalencia de prediabetes y diabetes en México: Ensanut 2022. Salud Pública México, 65, s163-s168. DOI: 10.21149/14832
Bavarva, J. H. & Narasimhacharya, A. V. (2008). Antihyperglycemic and hypolipidemic effects of Costus speciosus in alloxan induced diabetic rats. Phytotherapy Research, 22(5), 620-626. DOI: 10.1002/ptr.2302
Belfiore, A. (2007). The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Current Pharmaceutical Design, 13(7), 671–686. https://doi.org/10.2174/138161207780249173
Benny, M., Antony, B., Aravind, A., Gupta, K., Joseph, B. & Benny, I. (2020). Purification and characterization of anti-hyperglycemic bioactive molecule from Costus pictus d. don. International Journal of Pharmaceutical Sciences and Research, 11, 2075-2081. DOI: 10.13040/IJPSR.0975-8232.11(5).2075-81
Berrin, J. G., McLauchlan, W. R., Needs, P., Williamson, G., Puigserver, A., Kroon, P. A. & Juge, N. (2002). Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides. European Journal of Biochemistry, 269(1), 249–258. https://doi.org/10.1046/j.0014-2956.2001.02641.x
Bhuyan, B. & Chetia, D. (2020). In Vivo Validation of Folkloric Use of Costus pictus D. Don as Antidiabetic Plant in Assam, Using Streptozotocin Induced Wister Rat Model. Indian Journal of Clinical Biochemistry, 35(2), 225-231. DOI: 10.1007/s12291-019-00819-y
Binny, K., Kumar, S. G. & Dennis, T. (2010). Anti-inflammatory and antipyretic properties of the rhizome of Costus speciosus (koen.) sm. Journal of Basic and Clinical pharmacy, 1(3), 177-181. PMID: 24825984; PMCID: PMC3979190
Chen, G. F. & Schemske, D. W. (2019). Adaptation to seasonal drought in two closely related species of Neotropical Costus (Costaceae). Biotropica, 51(3), 311-315. http://doi.org/10.1111/btp.12645
Choi, J. H., Lee, K. A., Moon, J. H., Chon, S., Kim, D. J., Kim, H. J., Kim, N. H., Seo, J. A., Kim, M. K., Lim, J. H., Song, Y., Yang, Y. S., Kim, J. H., Lee, Y. B., Noh, J., Hur, K. Y., Park, J. S., Rhee, S. Y., Kim, H. J., Kim, H. M., Ko, J. H., Kim, N. H., Kim, C. H., Ahn, J., Oh, T. J., Kim, S. K., Kim, J., Han, E., Jin, S. M., Choi, W. S. & Moon, M. K. (2023). Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association. Diabetes & Metabolism Journal, 47(5), 575-594. Epub 2023 Sep 26. DOI: 10.4093/dmj.2023.0282
Cole, J. B. & Florez, J. C. (2020). Genetics of diabetes mellitus and diabetes complications. Nature Reviews Nephrology, 16(7), 377-390. DOI: 10.1038/s41581-020-0278-5
Cueva Chamba, A. M. (2023). Usos medicinales tradicionales y actividades biológicas de las especies del género Desmodium: una revisión de la literatura. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 22(6), 700-746. https://doi.org/10.37360/blacpma.23.22.6.51
Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., Rosas, S. E., Del Prato, S., Mathieu, C., Mingrone, G., Rossing, P., Tankova, T., Tsapas, A. & Buse, J. B. (2022). Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia, 65(12), 1925-1966. https://doi.org/10.1007/s00125-022-05787-2
Daisy, P., Eliza, J. & Ignacimuthu, S. (2008). Influence of Costus speciosus (Koen.) Sm. Rhizome extracts on biochemical parameters in streptozotocin induced diabetic rats. Journal of Health Science, 54(6), 675-681. https://doi.org/10.1248/jhs.54.675
Dharmalingam, M. & Yamasandhi, P. G. (2019). Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Indian Journal of Endocrinology and Metabolism, 22(3), 421-428. PMID: 30090738; PMCID: PMC6063173. DOI: 10.4103/ijem.IJEM_585_17
El Omari, N., Jaouadi, I., Lahyaoui, M., Benali, T., Taha, D., Bakrim, S. & Bouyahya, A. (2022). Natural sources, pharmacological properties, and health benefits of daucosterol: versatility of actions. Applied Sciences, 12(12), 5779. DOI: 10.3390/app12125779
Ediriweera, E. R. H. S. S. & Ratnasooriya, W. D. (2009). A review on herbs used in treatment of diabetes mellitus by Sri Lankan ayurvedic and traditional physicians. The AYU Journal, 30(4), 373–391. DOI:https://www.researchgate.net/publication/285706172
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D., Johnson, E. L., Kahan, S., Khunti, K., Leon, J., Lyons, S. K., Perry, M. L., Prahalad, P., Pratley, R. E., Seley, J. J., Stanton, R. C. & Gabbay, R. A. (2023). On behalf of the American Diabetes Association. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2023. Diabetes Care, 46(Suppl 1), S140-S157. PMID: 36507650; PMCID: PMC9810476. DOI: 10.2337/dc23-S009
Femi-Olabisi, F. J., Ishola, A. A., Faokunla, O., Agboola, A. O. & Babalola, B. A. (2021). Evaluation of the inhibitory potentials of selected compounds from Costus spicatus (Jacq.) rhizome towards enzymes associated with insulin resistance in polycystic ovarian syndrome: an in silico study. Journal Genetic Engineering & Biotechnology, 19(1), 176. https://doi.org/10.1186/s43141-021-00276-2
Fiory, F., Alberobello, A. T., Miele, C., Oriente, F., Esposito, I., Corbo, V., Ruvo, M., Tizzano, B., Rasmussen, T. E., Gammeltoft, S., Formisano, P. & Beguinot, F. (2005). Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling. Molecular and Cellular Biology, 25(24), 10803–10814. https://doi.org/10.1128/MCB.25.24.10803-10814.2005
Frasca, F., Pandini, G., Scalia, P., Sciacca, L., Mineo, R., Costantino, A., Goldfine, I. D., Belfiore, A. & Vigneri, R. (1999). Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Molecular and Cellular Biology, 19(5), 3278–3288. https://doi.org/10.1128/MCB.19.5.3278
Girgis, S. M., Shoman, T. M. T., Kassem, S. M., El-Din, A. E. & Abdel-Aziz, K. B. (2015). Potential protective effect of Costus speciosus or its nanoparticles on streptozotocin-induced genotoxicity and histopathological alterations in rats. Journal of Nutrition and Food Sciences, 5(3), S3-002 ref. 30. DOI: 10.4172/2155-9600.1000S3002
González-Barbosa, J., Hipólito-Nájera, A. R., Gómez-Balderas, R., Rodríguez-Laguna, N. & Moya-Hernández, R. (2023). Metformin, Chlorpropamide, and Glibenclamide: Interactions with Metal Ions and Cyclodextrins. Mini-Reviews in Organic Chemistry, 20, 1-23. DOI: https://doi.org/10.2174/1570193X20666230117105443
Guven, M., Aras, A. B., Akman, T., Sen, H. M., Ozkan, A., Salis, O., Sehitoglu, I., Kalkan, Y., Silan, C., Deniz, M. & Cosar, M. (2015). Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia. Iranian Journal of Basic Medical Sciences, 18(4), 356-363. PMID: 26019798; PMCID: PMC4439450
Han, X., Guo, J., Gao, Y., Zhan, J., You, Y. & Huang, W. (2021). Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue. Food & Function, 12(3), 1262-1270. PMID: 33434262. DOI:10.1039/d0fo02474k
Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H. & Ito, M. (2007). Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. The Journal of Biological Chemistry, 282(42), 30889–30900. https://doi.org/10.1074/jbc.M700832200
Heredia, V. V., Carlson, T. J., Garcia, E. & Sun, S. (2006). Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations. The Journal of Biological Chemistry, 281(52), 40201–40207. https://doi.org/10.1074/jbc.M607987200
Hermans, M. M., Kroos, M. A., van Beeumen, J., Oostra, B. A. & Reuser, A. J. (1991). Human lysosomal alpha-glucosidase. Characterization of the catalytic site. The Journal of Biological Chemistry, 266(21), 13507-13512. PMID: 1856189. https://doi.org/10.1016/S0021-9258(18)92727-4
Hermans, M. M., van Leenen, D., Kroos, M. A., Beesley, C. E., Van Der Ploeg, A. T., Sakuraba, H., Wevers, R., Kleijer, W., Michelakakis, H., Kirk, E. P., Fletcher, J., Bosshard, N., Basel-Vanagaite, L., Besley, G. & Reuser, A. J. (2004). Twenty-two novel mutations in the lysosomal alpha-glucosidase gene (GAA) underscore the genotype-phenotype correlation in glycogen storage disease type II. Human mutation, 23(1), 47–56. https://doi.org/10.1002/humu.10286
Hu, X. F., Liu, W. X., Zhang, R., Zhang, W., Wang, C., Chen, M. & Wang, Q. (2022). Essential oil from Saussurea costus inhibits proliferation and migration of Eca109 cells via mitochondrial apoptosis and STAT3 signaling. Asian Pacific Journal of Tropical Biomedicine, 12(6), 253-261. DOI: 10.4103/2221-1691.345517
International Diabetes Federation. IDF Diabetes Atlas, 11th. Brussels, Belgium: 2025. https://www.diabetesatlas.org
Instituto Nacional de Estadística y Geografía. Estadísticas a propósito del día mundial de la diabetes. Comunicado de prensa 645/21. México. INEGI,2021. https://www.inegi.org.mx/contenidos/saladeprensa/aproposito/2021/EAP_Dia
Ivanovski, O. & Drüeke, T. B. (2013). A new era in the treatment of calcium oxalate stones? Kidney International, 83(6), 998-1000. PMID: 23728004. DOI: 10.1038/ki.2013.41
Kalailingam, P., Kannaian, B., Tamilmani, E. & Kaliaperumal, R. (2014). Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 21(10), 1154–1161. https://doi.org/10.1016/j.phymed.2014.04.005
Khan, A. S. & Agarwal, S. (2022). Biopesticide activity of Costus igneus-A preliminary study. Journal of Clinical & Biomedical Research, 4(150), 2–3. https://doi.org/10.47363/JCBR/2022(4)150
Kasole, R., Martin, H. D. & Kimiywe, J. (2019). Traditional medicine and its role in the management of diabetes mellitus: “Patients’ and herbalists’ perspectives”. Evidence-Based Complementary and Alternative Medicine, 2019, 2835691. https://doi.org/10.1155/2019/2835691
King, H., Aubert, R. E. & Herman, W. H. (1998). Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care, 21(9), 1414–1431. https://doi.org/10.2337/diacare.21.9.1414
Latorre-Muro, P., Baeza, J., Armstrong, E. A., Hurtado-Guerrero, R., Corzana, F., Wu, L. E., Sinclair, D. A., López-Buesa, P., Carrodeguas, J. A. & Denu, J. M. (2018). Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions. Molecular Cell, 71(5), 718-732.e9. https://doi.org/10.1016/j.molcel.2018.07.031
Li, H., Li, Y., Zhang, X., Ren, G., Wang, L., Li, J. & Huang, X. (2021). The combination of Aquilaria sinensis (Lour.) Gilg and Aucklandia costus Falc. volatile oils exerts antidepressant effects in a CUMS-induced rat model by regulating the HPA axis and levels of neurotransmitters. Frontiers in Pharmacology, 11, 614413. https://doi.org/10.3389/fphar.2020.614413
Maruthur, N. M., Gribble, M. O., Bennett, W. L., Bolen, S., Wilson, L. M., Balakrishnan, P., Sahu, A., Bass, E., Kao, W. H. & Clark, J. M. (2014). The pharmacogenetics of type 2 diabetes: A systematic review. Diabetes Care, 37(3), 876–886. https://doi.org/10.2337/dc13-1276
Mechchate, H., Es-Safi, I., Mohamed Al Kamaly, O. & Bousta, D. (2021). Insight into gentisic acid antidiabetic potential using in vitro and in silico approaches. Molecules, 26(7),1932. https://doi.org/10.3390/molecules26071932
Medagama, A. B., Bandara, R., Abeysekera, R. A., Imbulpitiya, B. & Pushpakumari, T. (2014). Use of Complementary and Alternative Medicines (CAMs) among type 2 diabetes patients in Sri Lanka: A cross sectional survey. BMC Complementary and Alternative Medicine, 14, 374. https://doi.org/10.1186/1472-6882-14-374
Mi, H., Muruganujan, A., Huang, X., Ebert, D., Mills, C., Guo, X. & Thomas, P. D. (2019). Protocol for the PANTHER classification system (v.14.0). Nature Protocols, 14(3), 703–721. https://doi.org/10.1038/s41596-019-0128-8
Nusinovici, S., Sabanayagam, C., Teo, B. W., Tan, G. S. W. & Wong, T. Y. (2019). Vision impairment in CKD patients: Epidemiology, mechanisms, differential diagnoses, and prevention. American Journal of Kidney Diseases, 73(6), 846–857. https://doi.org/10.1053/j.ajkd.2018.12.047
Organización Mundial de la Salud. (2023). Diabetes. https://www.who.int/news-room/fact-sheets/detail/diabetes
Pandini, G., Frasca, F., Mineo, R., Sciacca, L., Vigneri, R. & Belfiore, A. (2002). Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. Journal of Biological Chemistry, 277(42), 39684–39695. https://doi.org/10.1074/jbc.M202766200
Pawar, V. & Pawar, P. (2014). Costus speciosus: An important medicinal plant. International Journal of Science and Research, 3(7), 28–33. www.ijsr.net
Perera, H. K., Premadasa, W. K. & Poongunran, J. (2016). α-glucosidase and glycation inhibitory effects of Costus speciosus leaves. BMC Complementary and Alternative Medicine, 16, 2. https://doi.org/10.1186/s12906-015-0982-z
Pittis, M. G., Donnarumma, M., Montalvo, A. L., Dominissini, S., Kroos, M., Rosano, C., Stroppiano, M., Bianco, M. G., Donati, M. A., Parenti, G., D’Amico, A., Ciana, G., Di Rocco, M., Reuser, A., Bembi, B. & Filocamo, M. (2008). Molecular and functional characterization of eight novel GAA mutations in Italian infants with Pompe disease. Human Mutation, 29(6), E27–E36. https://doi.org/10.1002/humu.20753
Porath, B., Gainullin, V. G., Cornec-Le Gall, E., Dillinger, E. K., Heyer, C. M., Hopp, K., Edwards, M. E., Madsen, C. D., Mauritz, S. R., Banks, C. J., Baheti, S., Reddy, B., Herrero, J. I., Bañales, J. M., Hogan, M. C., Tasic, V., Watnick, T. J., Chapman, A. B., Vigneau, C., Lavainne, F., Audrézet, M. P., Ferec, C., Le Meur, Y. & Torres, V. E. (2016). Mutations in GANAB, encoding the glucosidase IIα subunit, cause autosomal-dominant polycystic kidney and liver disease. American Journal of Human Genetics, 98(6), 1193–1207. https://doi.org/10.1016/j.ajhg.2016.05.004
Pujari, R. R. & Bandawane, D. D. (2021). Hepatoprotective activity of gentisic acid on 5-fluorouracil-induced hepatotoxicity in wistar rats. Turkish Journal of Pharmaceutical Sciences, 18(3), 332–340. https://doi.org/10.4274/tjps.galenos.2020.95870
Purba, F. R., Rahayu, I. & Timotius, K. H. (2023). Phytomolecules & pharmacology. Journal of Phytomolecule and Pharmacology, 2(2), 83–94. https://doi.org/10.56717/jpp.2023.v02i02.020
Qari, S. H. (2010). DNA-RAPD fingerprinting and cytogenetic screening of genotoxic and antigenotoxic effects of aqueous extracts of Costus speciosus (Koen). Journal of King Abdulaziz University: Science, 22, 133–152. https://doi.org/10.4197/Sci.22-1.10
Razliqi, R. N., Harooni, E., Neisi, N., Sameri, M. J. & Ahangarpour, A. (2023). Hepatoprotective effects of gentisic acid through its anti-oxidant properties in nicotinamide-streptozotocin induced diabetic mice. Iranian Journal of Basic Medical Sciences, 26(12), 1409–1415. https://doi.org/10.22038/IJBMS.2023.70659.15359
Riaz, U., Iqbal, S., Sohail, M. I., Samreen, T., Ashraf, M., Akmal, F. & Akhter, R. M. (2021). A comprehensive review on emerging importance and economical potential of medicinal and aromatic plants (MAPs) in current scenario. Pakistan Journal of Agricultural Research, 34(2), 381–392. https://dx.doi.org/10.17582/journal.pjar/2021/34.2.381.392
Rydberg, E. H., Sidhu, G., Vo, H. C., Hewitt, J., Côte, H. C., Wang, Y., Numao, S., MacGillivray, R. T., Overall, C. M., Brayer, G. D. & Withers, S. G. (1999). Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. Protein Science, 8(3), 635–643. https://doi.org/10.1110/ps.8.3.635
Shahid, S., Akhter, Z., Sukaina, M., Sohail, F. & Nasir, F. (2021). Association of diabetes with lower back pain: A narrative review. Cureus, 13(6), e15776. https://doi.org/10.7759/cureus.15776
Shinde, S. P. & Kondhalkar, S. M. (2025). A review on insulin plant (Costus igneus L.) and its remedial approaches. Asian Journal of Research in Botany, 8(1), 14–21. https://doi.org/10.9734/ajrib/2025/v8i1238
Singh, V. K., Yadav, K. S., Thomas, S. C., Gupta, A., Luqman, S., Shanker, K. & Yadav, N. P. (2024). An update on pharmacological and phytochemical aspects of Costus pictus D. Don—A promising anti-diabetic plant. Current Topics in Medicinal Chemistry, 24(9), 810-829. https://doi.org/10.2174/0115680266284994240118071737
Soladoye, M. O. & Oyesika, O. O. A. (2008). A textbook of medicinal plants from Nigeria. University of Lagos Press. https://opac.fuhsi.edu.ng/cgi-bin/koha/opac-detail.pl?biblionumber=42&shelfbrowse_itemnumber=76#holdings_panel
Stolar, M. (2009). Glycemic control and complications in type 2 diabetes mellitus. The American Journal of Medicine, 123(3, Suppl.), S3–S11. https://doi.org/10.1016/j.amjmed.2009.12.004
Subasinghe, H. W. A. S., Hettihewa, L. M. & Gunawardena, S. (2012). Rapid onset of action of Costus speciosus leaf extracts on insulin resistance in experimental Wistar rats. Proceedings of Annual Scientific Sessions of Faculty of Medical Sciences, 12, 28. https://journals.sjp.ac.lk/index.php/ASS/article/view/842
Sun, X. D., Cai, X. L., Pang, Q. Q., Zhou, M., Zhang, W., Chen, Y. S. & Bian, Q. (2021). First record of leaf spot disease on Costus speciosus caused by Nigrospora oryzae in Hainan, China. Plant Disease, 105(2), 506. https://doi.org/10.1094/PDIS-12-18-2181-PDN
Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., Mbanya, J. C., Pavkov, M. E., Ramachandaran, A., Wild, S. H., James, S., Herman, W. H., Zhang, P., Bommer, C., Kuo, S., Boyko, E. J. & Magliano, D. J. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice, 183, 109119. https://doi.org/10.1016/j.diabres.2021.109119
Takeda, J., Gidh-Jain, M., Xu, L. Z., Froguel, P., Velho, G., Vaxillaire, M., Cohen, D., Shimada, F., Makino, H., Nishi, S., Stoffel, M., Vionnet, N., St. Charles, R., Harrison, R. W., Weber, I. T., Bell, G. I. & Pilkis, S. J. (1993). Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants. Journal of Biological Chemistry, 268(20), 15200–15204. https://doi.org/10.1016/S0021-9258(18)82456-5
Tchamgoue, A. D., Tchokouaha, L. R. Y., Tsabang, N., Tarkang, P. A., Kuiate, J. R. & Agbor, G. A. (2018). Costus afer protects cardio-, hepato-, and reno-antioxidant status in streptozotocin-intoxicated Wistar rats. BioMed Research International, 2018, 4907648. https://doi.org/10.1155/2018/4907648
Tsukiyama, R., Katsura, H., Tokuriki, N. & Kobayashi, M. (2002). Antibacterial activity of licochalcone A against spore-forming bacteria. Antimicrobial Agents and Chemotherapy, 46(5), 1226–1230. https://doi.org/10.1128/AAC.46.5.1226-1230.2002
Valentini, G., Chiarelli, L. R., Fortin, R., Dolzan, M., Galizzi, A., Abraham, D. J., Wang, C., Bianchi, P., Zanella, A. & Mattevi, A. (2002). Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. Journal of Biological Chemistry, 277(26), 23807–23814. https://doi.org/10.1074/jbc.M202107200
Valluru, J. R. & Mani, S. (2009). Ethnobotanical information on medicinal plants for treatment of menstrual problems used by the tribes of salur mandal in Vizianagaram district, Andhra Pradesh, India. Journal of Phytological Research, 22(2), 335-337. https://www.jphytolres.org/system/files/old_papers/31_1.pdf
Verma, N. & Khosa, R. L. (2009). Evaluation of protective effect of ethanolic extract of Costus speciosus (Koen.) Sm. Rhizomes of carbon tetrachloride induced hepatotoxicity in rats. Natural Product Radiance, 8, 123-126. URL. https://nopr.niscpr.res.in/bitstream/123456789/4045/1/NPR%208%282%29%20123-126.pdf
Wang, J., Zhang, Y. S., Thakur, K., Hussain, S. S., Zhang, J. G., Xiao, G. R. & Wei, Z. J. (2018). Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest. Food and Chemical Toxicology, 120, 407-417. https://doi.org/10.1016/j.fct.2018.07.044
Xu, G., Liu, B., Sun, Y., Du, Y., Snetselaar, L. G., Hu, F. B. & Bao, W. (2018). Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study. British Medical Journal, 4, 362-1497. PMID: 30181166; PMCID: PMC6122253. DOI:10.1136/bmj.k1497
Yamazaki, H., Tsuge, H., Takahashi, O. & Uchida, R. (2021). Germacrane sesquiterpenes from leaves of Eupatorium chinense inhibit protein tyrosine phosphatase. Bioorganic & Medicinal Chemistry Letters, 53, 128422. https://doi.org/10.1016/j.bmcl.2021.128422
Zakir, M., Ahuja, N., Surksha, M. A., Sachdev, R., Kalariya, Y., Nasir, M., Kashif, M., Shahzeen, F., Tayyab, A., Khan, M. S. M., Junejo, M., Manoj, F., Varrassi, G., Kumar, S., Khatri, M. & Mohamad, T. (2023). Cardiovascular Complications of Diabetes: From Microvascular to Macrovascular Pathways. Cureus, 15(9), e45835. PMID: 37881393; PMCID: PMC10594042. DOI:10.7759/cureus.45835
Se declara que los Derechos de Autor de TIP Revista Especializada en Ciencias Químico-Biológicas de la Facultad de Estudios Superiores Zaragoza, pertenecen a la Universidad Nacional Autónoma de México
TIP Revista Especializada en Ciencias Químico-Biológicas está distribuido bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.
Se sugiere a los Autores que una vez que su artículo esté publicado en TIP Revista Especializada en Ciencias Químico-Biológicas, aparezca en los repositorios de las Instituciones a las que están adscritos, con la finalidad de que su difusión sea más amplia.

